Understanding the impact of sex and gender in Alzheimer's disease: A call to action

Rebecca A. Nebel; Neelum T. Aggarwal; Lisa L. Barnes; Aimee Gallagher; Jill M. Goldstein; Kejal Kantarci; Monica P. Mallampalli; Elizabeth C. Mormino; Laura Scott; Wai Haung Yu; Pauline M. Maki; Michelle M. Mielke

doi:10.1016/j.jalz.2018.04.008

Understanding the impact of sex and gender in Alzheimer's disease: A call to action

Rebecca A. Nebel, Neelum T. Aggarwal, Lisa L. Barnes, Aimee Gallagher, Jill M. Goldstein, Kejal Kantarci, Monica P. Mallampalli, Elizabeth C. Mormino, Laura Scott, Wai Haung Yu, Pauline M. Maki, Michelle M. Mielke

Research output: Contribution to journal › Article › peer-review

132 Scopus citations

Abstract

Introduction: Precision medicine methodologies and approaches have advanced our understanding of the clinical presentation, development, progression, and management of Alzheimer's disease (AD) dementia. However, sex and gender have not yet been adequately integrated into many of these approaches. Methods: The Society for Women's Health Research Interdisciplinary Network on AD, comprised of an expert panel of scientists and clinicians, reviewed ongoing and published research related to sex and gender differences in AD. Results: The current review is a result of this Network's efforts and aims to: (1) highlight the current state-of-the-science in the AD field on sex and gender differences; (2) address knowledge gaps in assessing sex and gender differences; and (3) discuss 12 priority areas that merit further research. Discussion: The exclusion of sex and gender has impeded faster advancement in the detection, treatment, and care of AD across the clinical spectrum. Greater attention to these differences will improve outcomes for both sexes.

Original language	English (US)
Pages (from-to)	1171-1183
Number of pages	13
Journal	Alzheimer's and Dementia
Volume	14
Issue number	9
DOIs	https://doi.org/10.1016/j.jalz.2018.04.008
State	Published - Sep 2018

Keywords

Alzheimer's disease
Biomarkers
Epidemiology
Gender
Hormones
Men
Menopause
Mild cognitive impairment
Risk factors
Sex
Women

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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10.1016/j.jalz.2018.04.008

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title = "Understanding the impact of sex and gender in Alzheimer's disease: A call to action",

abstract = "Introduction: Precision medicine methodologies and approaches have advanced our understanding of the clinical presentation, development, progression, and management of Alzheimer's disease (AD) dementia. However, sex and gender have not yet been adequately integrated into many of these approaches. Methods: The Society for Women's Health Research Interdisciplinary Network on AD, comprised of an expert panel of scientists and clinicians, reviewed ongoing and published research related to sex and gender differences in AD. Results: The current review is a result of this Network's efforts and aims to: (1) highlight the current state-of-the-science in the AD field on sex and gender differences; (2) address knowledge gaps in assessing sex and gender differences; and (3) discuss 12 priority areas that merit further research. Discussion: The exclusion of sex and gender has impeded faster advancement in the detection, treatment, and care of AD across the clinical spectrum. Greater attention to these differences will improve outcomes for both sexes.",

keywords = "Alzheimer's disease, Biomarkers, Epidemiology, Gender, Hormones, Men, Menopause, Mild cognitive impairment, Risk factors, Sex, Women",

author = "Nebel, {Rebecca A.} and Aggarwal, {Neelum T.} and Barnes, {Lisa L.} and Aimee Gallagher and Goldstein, {Jill M.} and Kejal Kantarci and Mallampalli, {Monica P.} and Mormino, {Elizabeth C.} and Laura Scott and Yu, {Wai Haung} and Maki, {Pauline M.} and Mielke, {Michelle M.}",

note = "Funding Information: This work was supported by a programmatic grant from Eli Lilly & Co. Publisher Copyright: {\textcopyright} 2018 the Alzheimer's Association",

year = "2018",

month = sep,

doi = "10.1016/j.jalz.2018.04.008",

language = "English (US)",

volume = "14",

pages = "1171--1183",

journal = "Alzheimer's and Dementia",

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AU - Goldstein, Jill M.

AU - Kantarci, Kejal

AU - Mallampalli, Monica P.

AU - Mormino, Elizabeth C.

AU - Scott, Laura

AU - Yu, Wai Haung

AU - Maki, Pauline M.

AU - Mielke, Michelle M.

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Understanding the impact of sex and gender in Alzheimer's disease: A call to action

Abstract

Keywords

ASJC Scopus subject areas

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