Abstract
Delayed graft function (DGF) is a common complication after kidney transplant. Despite extensive literature on the topic, the extant definition of DGF has not been conducive to advancing the scientific understanding of the influences and mechanisms contributing to its onset, duration, resolution, or long-term prognostic implications. In 2022, the National Kidney Foundation sponsored a multidisciplinary scientific workshop to comprehensively review the current state of knowledge about the diagnosis, therapy, and management of DGF and conducted a survey of relevant stakeholders on topics of clinical and regulatory interest. In this Special Report, we propose and defend a novel taxonomy for the clinical and research definitions of DGF, address key regulatory and clinical practice issues surrounding DGF, review the current state of therapies to reduce and/or attenuate DGF, offer considerations for clinical practice related to the outpatient management of DGF, and outline a prospective research and policy agenda.
Original language | English (US) |
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Pages (from-to) | 360-369 |
Number of pages | 10 |
Journal | American Journal of Kidney Diseases |
Volume | 83 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2024 |
Keywords
- acute kidney injury
- chronic kidney disease
- Delayed graft function
- graft survival
- kidney failure
- organ discard
- renal failure
- transplantation
ASJC Scopus subject areas
- Nephrology