Ultrasound surface wave elastography of the living human eye

Xiaoming Zhang; Jay McLaren; Arash Kazemi; Shuai Chun Lin; Christopher M. Pruet; Arthur J Sit

doi:10.1109/ULTSYM.2016.7728510

Ultrasound surface wave elastography of the living human eye

Xiaoming Zhang, Jay McLaren, Arash Kazemi, Shuai Chun Lin, Christopher M. Pruet, Arthur J Sit

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

The purpose of this paper was to demonstrate a noninvasive technique to measure elastic properties of human eyes using ultrasound surface wave elastography (USWE) technique. Twenty eyes of 10 healthy subjects (age 44-63; mean 51 years) were studied. A localized harmonic vibration for 0.1 second at 100 Hz was generated by using a spherically-tipped vibrator (3 mm diameter) placed on the closed eyelid. The subjects only felt a gentle vibration on their eyes. The wave propagation in the eye was measured by using a linear array ultrasound transducer. The wave speed was determined from the change in phase with distance. Mean wave speed in the cornea was 1.82 ± 0.10 m/s (± SD) at 100 Hz. Intraocular pressure (IOP) was measured by using Goldmann applanation tonometry. Mean IOP was 12.8 ± 2.7 mmHg (± SD). The wave speed correlated well with IOP (r=0.74; p<0.001). USWE is a safe and noninvasive technique for generating and measuring wave propagation in the eye. Further improvement and validation of USWE in the eye experiments is needed.

Original language	English (US)
Title of host publication	2016 IEEE International Ultrasonics Symposium, IUS 2016
Publisher	IEEE Computer Society
Volume	2016-November
ISBN (Electronic)	9781467398978
DOIs	https://doi.org/10.1109/ULTSYM.2016.7728510
State	Published - Nov 1 2016
Event	2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France Duration: Sep 18 2016 → Sep 21 2016

Other

Other	2016 IEEE International Ultrasonics Symposium, IUS 2016
Country/Territory	France
City	Tours
Period	9/18/16 → 9/21/16

Keywords

cornea
eye
surface wave elastography
ultrasound

ASJC Scopus subject areas

Acoustics and Ultrasonics

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10.1109/ULTSYM.2016.7728510

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title = "Ultrasound surface wave elastography of the living human eye",

abstract = "The purpose of this paper was to demonstrate a noninvasive technique to measure elastic properties of human eyes using ultrasound surface wave elastography (USWE) technique. Twenty eyes of 10 healthy subjects (age 44-63; mean 51 years) were studied. A localized harmonic vibration for 0.1 second at 100 Hz was generated by using a spherically-tipped vibrator (3 mm diameter) placed on the closed eyelid. The subjects only felt a gentle vibration on their eyes. The wave propagation in the eye was measured by using a linear array ultrasound transducer. The wave speed was determined from the change in phase with distance. Mean wave speed in the cornea was 1.82 ± 0.10 m/s (± SD) at 100 Hz. Intraocular pressure (IOP) was measured by using Goldmann applanation tonometry. Mean IOP was 12.8 ± 2.7 mmHg (± SD). The wave speed correlated well with IOP (r=0.74; p<0.001). USWE is a safe and noninvasive technique for generating and measuring wave propagation in the eye. Further improvement and validation of USWE in the eye experiments is needed.",

keywords = "cornea, eye, surface wave elastography, ultrasound",

author = "Xiaoming Zhang and Jay McLaren and Arash Kazemi and Lin, {Shuai Chun} and Pruet, {Christopher M.} and Sit, {Arthur J}",

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doi = "10.1109/ULTSYM.2016.7728510",

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AU - McLaren, Jay

AU - Kazemi, Arash

AU - Lin, Shuai Chun

AU - Pruet, Christopher M.

AU - Sit, Arthur J

PY - 2016/11/1

Y1 - 2016/11/1

N2 - The purpose of this paper was to demonstrate a noninvasive technique to measure elastic properties of human eyes using ultrasound surface wave elastography (USWE) technique. Twenty eyes of 10 healthy subjects (age 44-63; mean 51 years) were studied. A localized harmonic vibration for 0.1 second at 100 Hz was generated by using a spherically-tipped vibrator (3 mm diameter) placed on the closed eyelid. The subjects only felt a gentle vibration on their eyes. The wave propagation in the eye was measured by using a linear array ultrasound transducer. The wave speed was determined from the change in phase with distance. Mean wave speed in the cornea was 1.82 ± 0.10 m/s (± SD) at 100 Hz. Intraocular pressure (IOP) was measured by using Goldmann applanation tonometry. Mean IOP was 12.8 ± 2.7 mmHg (± SD). The wave speed correlated well with IOP (r=0.74; p<0.001). USWE is a safe and noninvasive technique for generating and measuring wave propagation in the eye. Further improvement and validation of USWE in the eye experiments is needed.

AB - The purpose of this paper was to demonstrate a noninvasive technique to measure elastic properties of human eyes using ultrasound surface wave elastography (USWE) technique. Twenty eyes of 10 healthy subjects (age 44-63; mean 51 years) were studied. A localized harmonic vibration for 0.1 second at 100 Hz was generated by using a spherically-tipped vibrator (3 mm diameter) placed on the closed eyelid. The subjects only felt a gentle vibration on their eyes. The wave propagation in the eye was measured by using a linear array ultrasound transducer. The wave speed was determined from the change in phase with distance. Mean wave speed in the cornea was 1.82 ± 0.10 m/s (± SD) at 100 Hz. Intraocular pressure (IOP) was measured by using Goldmann applanation tonometry. Mean IOP was 12.8 ± 2.7 mmHg (± SD). The wave speed correlated well with IOP (r=0.74; p<0.001). USWE is a safe and noninvasive technique for generating and measuring wave propagation in the eye. Further improvement and validation of USWE in the eye experiments is needed.

KW - cornea

KW - eye

KW - surface wave elastography

KW - ultrasound

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PB - IEEE Computer Society

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ER -

Ultrasound surface wave elastography of the living human eye

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