Ultrasound radiation force noninvasive bone assessment

Leighton Wan, Mathew Cheong, Max Denis, Mostafa Fatemi, Azra Alizad

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


In this work, a novel ultrasound-guided remote measurement technique is proposed for bone quality assessment. The technique utilizes an acoustic radiation force (ARF) excitation source to generate vibrational waves from the bone, and the ensuing radiating acoustic pressure is captured for analysis. Of particular interest, are extracting acoustic features related to the bone mechanical properties. Ex-vivo experiments of demineralized and intact (non-demineralized) bones are conducted, in order to determine the best acoustic features delineating the effects of demineralization. Mechanical tests demonstrate a reduction in the bone elastic modulus with demineralization. The acoustic waves from the intact bones travel faster than the demineralized bones. The spectra of the acoustic response of the demineralized bones exhibit higher attenuation for frequencies below 200 kHz in comparison to the intact bones. A time-frequency analysis exhibits a frequency shift with demineralization. Acoustic features related to these observations are extracted from the acoustic response of the bare bone experiments. Thereafter, attempts are made to recover these features from bone phantom experiments with overlaying tissue-like material. The results are summarized and discussed.

Original languageEnglish (US)
Title of host publication2015 IEEE International Ultrasonics Symposium, IUS 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479981823
StatePublished - Nov 13 2015
EventIEEE International Ultrasonics Symposium, IUS 2015 - Taipei, Taiwan, Province of China
Duration: Oct 21 2015Oct 24 2015

Publication series

Name2015 IEEE International Ultrasonics Symposium, IUS 2015


OtherIEEE International Ultrasonics Symposium, IUS 2015
Country/TerritoryTaiwan, Province of China


  • Bone Mineral Density
  • Osteopenia Screening
  • Ultrasound

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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