Ultrasound Elastography for Lung Disease Assessment

Boran Zhou, Xiaofeng Yang, Xiaoming Zhang, Walter J. Curran, Tian Liu

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Ultrasound elastography (US-E) is a noninvasive, safe, cost-effective and reliable technique to assess the mechanical properties of soft tissue and provide imaging biomarkers for pathological processes. Many lung diseases such as acute respiratory distress syndrome, chronic obstructive pulmonary disease, and interstitial lung disease are associated with dramatic changes in mechanical properties of lung tissues. Nevertheless, US-E is rarely used to image the lung because it is filled with air. The large difference in acoustic impedance between air and lung tissue results in the reflection of the ultrasound wave at the lung surface and, consequently, the loss of most ultrasound energy. In recent years, there has been an increasing interest in US-E applications in evaluating lung diseases. This article provides a comprehensive review of the technological advances of US-E research on lung disease diagnosis. We introduce the basic principles and major techniques of US-E and provide information on various applications in lung disease assessment. Finally, the potential applications of US-E to the diagnosis of COVID-19 pneumonia is discussed.

Original languageEnglish (US)
Article number9205585
Pages (from-to)2249-2257
Number of pages9
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Issue number11
StatePublished - Nov 2020


  • COVID-19 pneumonia
  • endobronchial ultrasound elastography (US-E)
  • lung cancer
  • lung disease
  • lung ultrasound surface wave elastography (LUSWE)
  • pulmonary fibrosis

ASJC Scopus subject areas

  • Instrumentation
  • Acoustics and Ultrasonics
  • Electrical and Electronic Engineering


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