@article{2835e6892acc4c598a7a210c7dcb3a90,
title = "Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway",
abstract = "Kurmi et al. report that the phosphocreatine (PCr) energy shuttle is important for breast tumor metabolism and growth. This energy shuttle is activated through MtCK1 Y153 phosphorylation by the HER2/ABL signaling axis. Using a creatine analog cyclocreatine that inhibits the PCr energy shuttle, they demonstrate reduced growth of trastuzumab-resistant breast tumors in mice.",
keywords = "ABL kinase, HER2 tyrosine kinase, breast cancer, cyclocreatine, mitochondria, mitochondrial bioenergetics, mitochondrial creatine kinase, oncogenic tyrosine kinase, phosphocreatine, tyrosine phosphorylation",
author = "Kiran Kurmi and Sadae Hitosugi and Jia Yu and Felix Boakye-Agyeman and Wiese, {Elizabeth K.} and Larson, {Thomas R.} and Qing Dai and Machida, {Yuichi J.} and Zhenkun Lou and Liewei Wang and Boughey, {Judy C.} and Kaufmann, {Scott H.} and Goetz, {Matthew P.} and Karnitz, {Larry M.} and Taro Hitosugi",
note = "Funding Information: This research was supported in part by NIH R01 CA225680 (to T.H.), CA196648 (to L.W.), Career Catalyst Research funding ( CCR14300798 ) from the Susan G. Komen Foundation (to T.H.), the Eagles Cancer Research Fund (to T.H.), a Team Science Platform Award from the Mayo Clinic Center for Biomedical Discovery (to T.H. and Z.L.), the Developmental Therapeutics Program from the Mayo Clinic Cancer Center (to T.H.), the Minnesota Partnership for Biotechnology and Medical Genomics grant NP IF no. 16.09 (to S.H.K), the Mayo Clinic Center for Individualized Medicine, Nadia's Gift Foundation , John P. Guider , The Eveleigh Family , the Mayo Clinic Cancer Center grant CA15083-40A2 (to M.P.G.), George M. Eisenberg Foundation for Charities, the Prospect Creek Foundation , the Randy Shaver Cancer Research and Community Fund , and the Mayo Clinic Breast SPORE P50CA 116201-10 (to T.H. and M.P.G.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. K.K., E.K.W., and T.R.L. were supported by predoctoral fellowships from the Mayo Foundation for Education and Research. E.K.W. was supported by NIH T32 GM072424 . We thank the Mayo Clinic Cancer Center Pharmacology Shared Resource (supported by P30 CA15083-40 ) for providing tissue culture facilities and HPLC analytical expertise. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = dec,
day = "4",
doi = "10.1016/j.cmet.2018.08.008",
language = "English (US)",
volume = "28",
pages = "833--847.e8",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "6",
}