Type ii collagen—induced arthritis in mice

Paul H. Wooley, Harvinder S. Luthra, Christopher J. Krco, John M. Stuart, Chella S. David

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


The passive transfer of high levels of anti‐type II collagen antibody from mice with type II collagen‐induced arthritis may transfer arthritis to syngeneic recipient animals. However, the transfer of either arthritogenic or sub‐arthritogenic doses of polyclonal anti‐type II collagen antibody, or non‐arthritogenic monoclonal anti‐type II collagen antibody may protect mice against the subsequent induction of arthritis by type II collagen. A protective effect was also observed in mice given free native type II collagen intravenously before the administration of collagen in an arthritogenic protocol.

Original languageEnglish (US)
Pages (from-to)1010-1017
Number of pages8
JournalArthritis & Rheumatism
Issue number9
StatePublished - Sep 1984

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)


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