Two enabling architectures for DNA-templated organic synthesis

Zev J. Gartner, Rozalina Grubina, Christopher T. Calderone, David R. Liu

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


Reactivity can be rationally manipulated in DNA-templated synthesis by altering the design of template architectures: a) The omega (Ω) architecture enables DNA-templated reactions to be encoded by bases distal from the reactive end of the template, regardless of the distance dependence of the reaction. b) The T architecture enables two DNA-templated reactions to take place on a single template in one solution, as illustrated.

Original languageEnglish (US)
Pages (from-to)1370-1375
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number12
StatePublished - Mar 28 2003


  • Bioorganic chemistry
  • Combinatorial chemistry
  • DNA
  • Template synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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