@article{ba71052679584ee0834e1ebe8777547e,
title = "Tumor selective uptake of drug-nanodiamond complexes improves therapeutic outcome in pancreatic cancer",
abstract = "Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related deaths and novel treatment approaches are urgently needed. Here we show that poly(ethylene glycol)-functionalized nanodiamonds loaded with doxorubicin (ND-PEG-DOX) afforded a considerable improvement over free drug in an orthotopic pancreatic xenograft model. ND-PEG-DOX complexes were also superior to free DOX in 3-dimensional (3D) tumor spheroids of PDAC. ND-PEG showed no cytotoxicity towards macrophages, and histopathological analysis showed no abnormalities of major organs upon in vivo administration of ND-PEG-DOX. These results provide evidence that ND-mediated drug delivery may serve as a means of improving the therapeutic outcome in PDAC.",
keywords = "Drug delivery, Nanodiamonds, Nanomedicine, Pancreatic adenocarcinoma",
author = "Madamsetty, {Vijay S.} and Anil Sharma and Maria Toma and Stefanie Samaniego and Audrey Gallud and Enfeng Wang and Krishnendu Pal and Debabrata Mukhopadhyay and Bengt Fadeel",
note = "Funding Information: Funding: This work was supported by the Swedish Cancer Foundation (CAN 2018/500), European Commission through the Seventh Framework Programme (FP7-NANOSOLUTIONS, grant agreement no. 309329), Swedish Foundation for International Cooperation in Research and Higher Education (STINT), NIH grants CA150190 and CA78383, Florida Department of Health Cancer Research Chair Fund, and through a Karolinska Institutet-Mayo Clinic collaborative grant awarded to B.F. and D.M. Funding: This work was supported by the Swedish Cancer Foundation (CAN 2018/500), European Commission through the Seventh Framework Programme (FP7-NANOSOLUTIONS, grant agreement no. 309329), Swedish Foundation for International Cooperation in Research and Higher Education (STINT), NIH grants CA150190 and CA78383, Florida Department of Health Cancer Research Chair Fund, and through a Karolinska Institutet-Mayo Clinic collaborative grant awarded to B.F. and D.M. The authors thank Kjell Hultenby, Electron Microscopy Core Facility at Karolinska Institutet, and John E. Charlesworth, Mayo Microscopy and Cell Analysis Core Facility for assistance with TEM, Shamit K. Dutta for assistance with animal experiments, Laura J. Lewis-Tuffin for assistance with imaging, and Brandy Edenfield for IHC sectioning and staining. PlasmaChem GmbH (Berlin, Germany) is acknowledged for providing the NDs. Funding: This work was supported by the Swedish Cancer Foundation (CAN 2018/500), European Commission through the Seventh Framework Programme (FP7-NANOSOLUTIONS, grant agreement no. 309329), Swedish Foundation for International Cooperation in Research and Higher Education (STINT), NIH grants CA150190 and CA78383, Florida Department of Health Cancer Research Chair Fund, and through a Karolinska Institutet-Mayo Clinic collaborative grant awarded to B.F. and D.M. Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = jun,
doi = "10.1016/j.nano.2019.02.020",
language = "English (US)",
volume = "18",
pages = "112--121",
journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",
issn = "1549-9634",
publisher = "Elsevier Inc.",
}