Tumor angiogenesis, vascularization, and contrast-enhanced magnetic resonance imaging

Zaver M. Bhujwalla, Dmitri Artemov, James Glockner

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations


Angiogenesis, the process by which new blood vessels are generated, occurs during wound healing, in the female reproductive system during ovulation and gestation, and during embryonic development. The process is carefully controlled with positive and negative regulators, because several vital physiological functions require angiogenesis. The consequences of abnormal angiogenesis are either excessive or insufficient blood vessel growth. Ulcers, strokes, and heart attacks can result from the absence of angiogenesis normally required for natural healing, whereas excessive blood vessel proliferation may favor tumor growth and dissemination, blindness, and arthritis. In this review, the process of angiogenesis and the characteristics of the resulting tumor vasculature are outlined. Contrast- enhanced magnetic resonance imaging techniques that currently are available for basic research and clinical applications to study various aspects of tumor angiogenesis and neovascularization are discussed.

Original languageEnglish (US)
Pages (from-to)92-103
Number of pages12
JournalTopics in Magnetic Resonance Imaging
Issue number2
StatePublished - Apr 1999


  • Angiogenesis
  • Cancer
  • Contrast-enhanced magnetic resonance imaging
  • Vascularization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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