TY - JOUR
T1 - TSLP signaling pathway map
T2 - A platform for analysis of TSLP-mediated signaling
AU - Zhong, Jun
AU - Sharma, Jyoti
AU - Raju, Rajesh
AU - Palapetta, Shyam Mohan
AU - Prasad, T. S.Keshava
AU - Huang, Tai Chung
AU - Yoda, Akinori
AU - Tyner, Jeffrey W.
AU - Van Bodegom, Diederik
AU - Weinstock, David M.
AU - Ziegler, Steven F.
AU - Pandey, Akhilesh
N1 - Funding Information:
National Heart Lung and Blood Institute (HHSN268201000032C to A.P.) and an NIH Roadmap grant 'Technology Center for Networks and Pathways' (U54 GM103520 to A.P.). Senior Research fellowship award from Council of Scientific and Industrial Research (CSIR) (to J.S. and S.M.P.).
Funding Information:
National Heart Lung and Blood Institute (HHSN268201000032C to A.P.) and an NIH Roadmap grant ‘Technology Center for Networks and Pathways’ (U54 GM103520 to A.P.). Senior Research fellowship award from Council of Scientific and Industrial Research (CSIR) (to J.S. and S.M.P.).
Publisher Copyright:
© The Author(s) 2014.
PY - 2014
Y1 - 2014
N2 - Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and inthe differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an interleukin-7 receptor α chain and a unique TSLP receptor (TSLPR) [also known as cytokine receptor-like factor 2 (CRLF2)]. Cellular targets of TSLP include dendritic cells, B cells, mast cells, regulatory T (Treg) cells and CD4+ and CD8+ T cells. The TSLP/TSLPR axis can activate multiple signaling transduction pathways including the JAK/STAT pathway and the PI-3 kinase pathway. Aberrant TSLP/TSLPR signaling has been associated with a variety of human diseases including asthma, atopic dermatitis, nasal polyposis, inflammatory bowel disease, eosinophilic eosophagitis and, most recently, acute lymphoblastic leukemia. A centralized resource of the TSLP signaling pathway cataloging signaling events is not yet available. In this study, we present a literature-annotated resource of reactions in the TSLP signaling pathway. This pathway map is publicly available through NetPath (http://www.netpath.org/), an open access signal transduction pathway resource developed previously by our group. This map includes 236 molecules and 252 reactions that are involved in TSLP/TSLPR signaling pathway. We expect that the TSLP signaling pathway map will provide a rich resource to study the biology of this important cytokine as well as to identify novel therapeutic targets for diseases associated with dysregulated TSLP/TSLPR signaling.
AB - Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and inthe differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an interleukin-7 receptor α chain and a unique TSLP receptor (TSLPR) [also known as cytokine receptor-like factor 2 (CRLF2)]. Cellular targets of TSLP include dendritic cells, B cells, mast cells, regulatory T (Treg) cells and CD4+ and CD8+ T cells. The TSLP/TSLPR axis can activate multiple signaling transduction pathways including the JAK/STAT pathway and the PI-3 kinase pathway. Aberrant TSLP/TSLPR signaling has been associated with a variety of human diseases including asthma, atopic dermatitis, nasal polyposis, inflammatory bowel disease, eosinophilic eosophagitis and, most recently, acute lymphoblastic leukemia. A centralized resource of the TSLP signaling pathway cataloging signaling events is not yet available. In this study, we present a literature-annotated resource of reactions in the TSLP signaling pathway. This pathway map is publicly available through NetPath (http://www.netpath.org/), an open access signal transduction pathway resource developed previously by our group. This map includes 236 molecules and 252 reactions that are involved in TSLP/TSLPR signaling pathway. We expect that the TSLP signaling pathway map will provide a rich resource to study the biology of this important cytokine as well as to identify novel therapeutic targets for diseases associated with dysregulated TSLP/TSLPR signaling.
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U2 - 10.1093/database/bau007
DO - 10.1093/database/bau007
M3 - Article
C2 - 24573880
AN - SCOPUS:84906655742
SN - 1758-0463
VL - 2014
JO - Database
JF - Database
ER -