Trophic factor expression in phrenic motor neurons

Carlos B. Mantilla, Gary C. Sieck

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The function of a motor neuron and the muscle fibers it innervates (i.e., a motor unit) determines neuromotor output. Unlike other skeletal muscles, respiratory muscles (e.g., the diaphragm, DIAm) must function from birth onwards in sustaining ventilation. DIAm motor units are capable of both ventilatory and non-ventilatory behaviors, including expulsive behaviors important for airway clearance. There is significant diversity in motor unit properties across different types of motor units in the DIAm. The mechanisms underlying the development and maintenance of motor unit diversity in respiratory muscles (including the DIAm) are not well understood. Recent studies suggest that trophic factor influences contribute to this diversity. Remarkably little is known about the expression of trophic factors and their receptors in phrenic motor neurons. This review will focus on the contribution of trophic factors to the establishment and maintenance of motor unit diversity in the DIAm, during development and in response to injury or disease.

Original languageEnglish (US)
Pages (from-to)252-262
Number of pages11
JournalRespiratory Physiology and Neurobiology
Issue number1-2
StatePublished - Dec 10 2008


  • Development
  • Diaphragm
  • Glial cell line-derived neurotrophic factor
  • Neuregulin
  • Neurotrophin
  • Respiratory muscles
  • Skeletal muscle

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine


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