Trisomy 6 as a primary karyotypic aberration in hematologic disorders

Anwar N. Mohamed, Mary L. Varterasian, Sheila M. Dobin, Thomas S. McConnell, Sandra R. Wolman, Cathryn Rankin, Cheryl L. Willman, David R. Head, Marilyn L. Slovak

Research output: Contribution to journalArticlepeer-review


We identified seven patients with hematologic disorders and trisomy 6 as the sole karyotypic aberration in bone marrow aspirates or unstimulated peripheral blood. Five patients were male and two were female; all were adults with ages ranging from 22 to 74 years. Three of the seven patients presented with manifestations of peripheral cytopenia. Their bone marrows were hypocellular with slight or no dysplastic changes and without an increase in blasts. One of these patients subsequently developed acute myeloid leukemia (AML-M1). The four remaining patients were initially diagnosed with AML - three consistent with French-American-British classification of M1 and M4 in the fourth patient. These results suggest that trisomy 6 is a nonrandom primary numerical anomaly of myeloid disorders. The association of cytopenia and hypoplastic bone marrow with trisomy 6 may constitute a new, distinctive variant among myelodysplastic syndromes.

Original languageEnglish (US)
Pages (from-to)152-155
Number of pages4
JournalCancer Genetics and Cytogenetics
Issue number2
StatePublished - Oct 1998

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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