Trigeminal Autonomic Cephalalgias

Mark J. Burish, Todd D. Rozen

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


The trigeminal autonomic cephalalgias (TACs) are a group of primary headache syndromes all marked by unilateral headache and ipsilateral cranial autonomic features. The TACs include cluster headache, paroxysmal hemicrania, short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing, and hemicrania continua. Pathophysiology includes the trigeminal pain system, autonomic system, hypothalamus, and more recently an identified role for the vagus nerve. Diagnosis is made after looking at headache frequency, duration, and accompanying symptoms. Each TAC has its own unique treatment, which is discussed in depth.

Original languageEnglish (US)
Pages (from-to)847-869
Number of pages23
JournalNeurologic clinics
Issue number4
StatePublished - Nov 2019


  • Cluster headache
  • Hemicrania continua
  • Paroxysmal hemicrania
  • SUNA
  • Trigeminal autonomic cephalalgia

ASJC Scopus subject areas

  • Clinical Neurology


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