Tremor, Holmes

S. H. Mehta, K. D. Sethi

Research output: Chapter in Book/Report/Conference proceedingChapter


Holmes tremor (HT) is both a resting and kinetic tremor (<4.5Hz) and results from lesions involving both the cerebellorubro-thalamic and nigrostriatal pathways. HT is difficult to treat with pharmacotherapy, although several antiepileptics, anticholinergics, clonazepam, isoniazid, and dopaminergic medications have been tried. Surgical treatment of HT revolves around lesioning or stimulation of thalamic or globus pallidus targets or combinations thereof. However, research in identifying newer targets with more efficacy in controlling tremor is necessary in the future.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Movement Disorders
PublisherElsevier Inc.
Number of pages2
ISBN (Electronic)9780123741059
ISBN (Print)9780123741011
StatePublished - Jan 1 2010


  • Deep brain stimulation for Holmes tremor
  • Holmes tremor
  • Midbrain tremor
  • Rubral tremor

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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