Treatment Recommendations for the Use of Antipsychotics for Aggressive Youth (TRAAY). Part II

Elizabeth Pappadopulos, James C. MacIntyre, M. Lynn Crismon, Robert L. Findling, Richard P. Malone, Albert Derivan, Nina Schooler, Lin Sikich, Laurence Greenhill, Sarah B. Schur, Chip J. Felton, Harvey Kranzler, David M. Rube, Jeffrey Sverd, Molly Finnerty, Scott Ketner, Sonja E. Siennick, Peters S. Jensen

Research output: Contribution to journalArticlepeer-review

198 Scopus citations


Objective: To develop treatment recommendations for the use of antipsychotic medications for children and adolescents with serious psychiatric disorders and externalizing behavior problems. Method: Using a combination of evidence- and consensus-based methodologies, recommendations were developed in six phases as informed by three primary sources of information: (1) current scientific evidence (published and unpublished), (2) the expressed needs for treatment-relevant information and guidance specified by clinicians in a series of focus groups, and (3) consensus of clinical and research experts derived from a formal survey and a consensus workshop. Results: Fourteen treatment recommendations on the use of atypical antipsychotics for aggression in youth with comorbid psychiatric conditions were developed. Each recommendation corresponds to one of the phases of care (evaluation, treatment, stabilization, and maintenance) and includes a brief clinical rationale that draws upon the available scientific evidence and consensus expert opinion derived from survey data and a consensus workshop. Conclusion: Until additional research from controlled trials becomes available, these evidence- and consensus-based treatment recommendations may be a useful approach to guide the use of antipsychotics in youth with aggression.

Original languageEnglish (US)
Pages (from-to)145-161
Number of pages17
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Issue number2
StatePublished - Feb 2003


  • Aggression
  • Atypical antipsychotic medications
  • Child and adolescent psychopathology
  • Treatment recommendations

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health


Dive into the research topics of 'Treatment Recommendations for the Use of Antipsychotics for Aggressive Youth (TRAAY). Part II'. Together they form a unique fingerprint.

Cite this