Treatment of rheumatoid arthritis with higher dose intravenous methotrexate

S. Gabriel; E. Creagan; W. M. O'Fallon; J. Jaquith; T. W. Bunch

Treatment of rheumatoid arthritis with higher dose intravenous methotrexate

S. Gabriel, E. Creagan, W. M. O'Fallon, J. Jaquith, T. W. Bunch

Quantitative Health Sciences

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14 Scopus citations

Abstract

A pilot study evaluated intravenous methotrexate (MTX) (initial dose 40 mg/m²; final dose, 26 mg/m²), weekly for 12 weeks in 10 patients with rheumatoid arthritis who failed oral MTX. Statistically significant differences were noted for all the response variables examined: joint count (p = 0.0017), morning stiffness (p = 0.014), global assessment (patient, p = 0.0032, physician, p = 0.029), Arthritis Impact Measurement Scale (p = 0.0004), erythrocyte sedimentation rate (p = 0.012), grip strength (right p = 0.044, left p = 0.011). All 7 patients who completed the 12-week treatment period fulfilled the predetermined criteria for response. Intravenous MTX at these doses has potential efficacy in this patient group.

Original language	English (US)
Pages (from-to)	460-465
Number of pages	6
Journal	Journal of Rheumatology
Volume	17
Issue number	4
State	Published - Jan 1 1990

Keywords

methotrexate
rheumatoid arthritis
treatment

ASJC Scopus subject areas

Rheumatology
Immunology and Allergy
Immunology

Cite this

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title = "Treatment of rheumatoid arthritis with higher dose intravenous methotrexate",

abstract = "A pilot study evaluated intravenous methotrexate (MTX) (initial dose 40 mg/m2; final dose, 26 mg/m2), weekly for 12 weeks in 10 patients with rheumatoid arthritis who failed oral MTX. Statistically significant differences were noted for all the response variables examined: joint count (p = 0.0017), morning stiffness (p = 0.014), global assessment (patient, p = 0.0032, physician, p = 0.029), Arthritis Impact Measurement Scale (p = 0.0004), erythrocyte sedimentation rate (p = 0.012), grip strength (right p = 0.044, left p = 0.011). All 7 patients who completed the 12-week treatment period fulfilled the predetermined criteria for response. Intravenous MTX at these doses has potential efficacy in this patient group.",

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T1 - Treatment of rheumatoid arthritis with higher dose intravenous methotrexate

AU - Gabriel, S.

AU - Creagan, E.

AU - O'Fallon, W. M.

AU - Jaquith, J.

AU - Bunch, T. W.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - A pilot study evaluated intravenous methotrexate (MTX) (initial dose 40 mg/m2; final dose, 26 mg/m2), weekly for 12 weeks in 10 patients with rheumatoid arthritis who failed oral MTX. Statistically significant differences were noted for all the response variables examined: joint count (p = 0.0017), morning stiffness (p = 0.014), global assessment (patient, p = 0.0032, physician, p = 0.029), Arthritis Impact Measurement Scale (p = 0.0004), erythrocyte sedimentation rate (p = 0.012), grip strength (right p = 0.044, left p = 0.011). All 7 patients who completed the 12-week treatment period fulfilled the predetermined criteria for response. Intravenous MTX at these doses has potential efficacy in this patient group.

AB - A pilot study evaluated intravenous methotrexate (MTX) (initial dose 40 mg/m2; final dose, 26 mg/m2), weekly for 12 weeks in 10 patients with rheumatoid arthritis who failed oral MTX. Statistically significant differences were noted for all the response variables examined: joint count (p = 0.0017), morning stiffness (p = 0.014), global assessment (patient, p = 0.0032, physician, p = 0.029), Arthritis Impact Measurement Scale (p = 0.0004), erythrocyte sedimentation rate (p = 0.012), grip strength (right p = 0.044, left p = 0.011). All 7 patients who completed the 12-week treatment period fulfilled the predetermined criteria for response. Intravenous MTX at these doses has potential efficacy in this patient group.

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KW - rheumatoid arthritis

KW - treatment

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Treatment of rheumatoid arthritis with higher dose intravenous methotrexate

Abstract

Keywords

ASJC Scopus subject areas

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