Treatment of reflex sympathetic dystrophy with topical capsaicin. Case report

William P. Cheshire, Clyde R. Snyder

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


A 31-year-old woman with intractable reflex sympathetic dystrophy experienced nearly complete, though temporary, resolution of pain following 3 weeks of topical capsaicin. We propose that capsaicin may be a useful treatment for reflex sympathetic dystrophy, either by depleting substance P from primary afferent neurons that mediate allodynia, or by modulating sympathetic efferent activity.

Original languageEnglish (US)
Pages (from-to)307-311
Number of pages5
Issue number3
StatePublished - Sep 1990


  • Allodynia
  • Capsaicin
  • Reflex sympathetic dystrophy
  • Substance P

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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