Treatment of primary systemic amyloidosis (AL): Role of intensive and standard therapy

Taimur Sher, Suzanne R. Hayman, Morie A. Gertz

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Immunoglobulin light-chain (AL) amyloidosis is a clonal plasma cell dyscrasia. Delay in diagnosis is the major hurdle in improving the outcomes of AL patients. Almost all patients with systemic AL need cytotoxic therapy. Treatment can improve symptoms and quality of life, as well as extend survival. Supportive care is an integral part of the treatment plan. Severity of cardiac involvement is an important determinant of prognosis and influences the choice of therapy. Cardiac biomarkers and serum free light chain assay are important tools for assessing prognosis and monitoring treatment response. Myeloablative chemotherapy with melphalan and autologous stem cell rescue appears to offer survival benefit; however, it is an option for only a quarter of AL patients. Standarddose combination chemotherapy with steroids and alkylating agents is a safe and effective treatment strategy that can result in improvement of organ function in many patients. Newer agents such as bortezomib and lenalidomide have shown promising activity and are being evaluated as part of combination regimens in clinical trials.

Original languageEnglish (US)
Pages (from-to)644-651
Number of pages8
JournalClinical Advances in Hematology and Oncology
Issue number10
StatePublished - Oct 1 2012


  • Amyloidosis
  • Chemotherapy
  • Immunoglobulin light-chain
  • Stem cell transplantation

ASJC Scopus subject areas

  • Hematology
  • Oncology


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