Treatment of Osteoporosis

Daniel Woodard, Linda S. Richelson, Heinz W. Wahner, L. J. Melton, B. Lawrence Riggs

Research output: Contribution to journalLetterpeer-review


To the Editor: Richelson et al. (Nov. 15 issue)1 make an important point about postmenopausal osteoporosis: the presence of estrogen helps prevent bone loss. But why is estrogen effective? Is it the most effective hormonal treatment? As Nuti and co-workers2 have shown, anabolic steroids have an even more pronounced effect and can in fact produce a prolonged increase in bone calcium in postmenopausal patients. It would appear that estrogen's osteogenic effects occur not because of its estrogenic properties themselves but because it is also weakly anabolic. This helps explain why women slowly lose bone calcium even with normally functioning ovaries,.

Original languageEnglish (US)
Pages (from-to)647
Number of pages1
JournalNew England Journal of Medicine
Issue number10
StatePublished - Mar 7 1985

ASJC Scopus subject areas

  • General Medicine


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