Treatment of hepatitis B virus-associated nephropathy

Usama Elewa, Ana Maria Sandri, W. Ray Kim, Fernando C. Fervenza

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Epidemiological studies have shown a relationship between hepatitis B virus (HBV) infection and development of proteinuria in some patients (most commonly children), with a predominance for male gender and histological findings of membranous nephropathy on renal biopsy. The presence of immune complexes in the kidney suggests an immune complex basis for the disease, but a direct relation between HBV and membranous nephropathy (or other types of glomerular diseases) remains to be proven. Clearance of HBV antigens, either spontaneous or following antiviral treatments results in improvement in proteinuria. Thus, prompt recognition and specific antiviral treatment are critical in managing patients with HBV and renal involvement. The present review focuses on treatment of HBV with special emphasis given to antiviral therapies, its complications, and dosing in patients with HBV-associated kidney disease.

Original languageEnglish (US)
Pages (from-to)c41-c49
JournalNephron - Clinical Practice
Issue number1
StatePublished - Aug 2011


  • Antiviral therapy
  • Hepatitis B virus
  • Immunosuppressive therapy
  • Nephropathy

ASJC Scopus subject areas

  • Nephrology


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