Treatment advances in liver-limited metastatic colorectal cancer

Steven R. Alberts, Graeme J. Poston

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Over the last several decades advances in the management and treatment of patients with liver metastases from colorectal cancer (CRC) has changed a disease with a dismal prognosis to one with a potential for cure in some patients. Advances have been made through coordinated management of patients by surgeons, medical oncologists, radiologists, and other health care professionals coupled with advances in treatment options. Although these advances have clearly impacted patient outcomes, it is clear that the benefit of traditional surgical approaches and the use of cytoxic chemotherapy are reaching a plateau. Continued research to develop new and more active therapies, including targeted or biologic agents, is needed. This review discusses the advances made in management of patients with liver-limited metastatic disease.

Original languageEnglish (US)
Pages (from-to)258-265
Number of pages8
JournalClinical colorectal cancer
Issue number4
StatePublished - Dec 2011


  • Colorectal cancer
  • Liver metastases
  • Metachronous metastasis
  • Resectability
  • Synchronous metastasis

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology


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