TY - JOUR
T1 - Transposition of the great arteries and hypocalcemia in a patient with fetal hydantoin syndrome
AU - Shah, Mrugeshkumar K.
AU - Morava, Eva
AU - Gill, William
AU - Marble, Michael R.
PY - 2002
Y1 - 2002
N2 - We report a patient with fetal hydantoin syndrome (FHS) with associated d-transposition of the great arteries (d-TGA) and persistent hypocalcemia. d-TGA and hypocalcemia have each been individually reported once in association with FHS, but these patients were also prenatally exposed to phenobarbital. To our knowledge, this is the first report of these problems occurring after prenatal exposure to hydantoin alone. The combination of congenital heart disease and hypocalcemia in our patient raises the possibility of a hydantoin effect on neural crest migration.
AB - We report a patient with fetal hydantoin syndrome (FHS) with associated d-transposition of the great arteries (d-TGA) and persistent hypocalcemia. d-TGA and hypocalcemia have each been individually reported once in association with FHS, but these patients were also prenatally exposed to phenobarbital. To our knowledge, this is the first report of these problems occurring after prenatal exposure to hydantoin alone. The combination of congenital heart disease and hypocalcemia in our patient raises the possibility of a hydantoin effect on neural crest migration.
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U2 - 10.1038/sj.jp.7210596
DO - 10.1038/sj.jp.7210596
M3 - Article
C2 - 11840251
AN - SCOPUS:85047697604
SN - 0743-8346
VL - 22
SP - 89
EP - 90
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 1
ER -