Transplantation in the sensitized recipient and across ABO blood groups

Research output: Chapter in Book/Report/Conference proceedingChapter


Alloantibody toward human leukocyte antigens (HLAs) and blood antigens is a major barrier to successful transplantation. This chapter discusses the current options for transplantation in sensitized renal transplant candidates or those with ABO-incompatible living donors. Specific emphasis is placed on what is known regarding the mechanisms and treatment of both early and late antibody-mediated injury, including the results of some recent therapeutic trials. Finally, current knowledge regarding the mechanism of antibody production in the setting of renal transplantation is outlined, highlighting important gaps in current knowledge in this emerging field.

Original languageEnglish (US)
Title of host publicationKidney Transplantation - Principles and Practice
Number of pages12
ISBN (Electronic)9780323531863
StatePublished - Jan 1 2019


  • Crossmatch
  • Desensitization
  • Donor specific antibody
  • Kidney transplantation
  • Sensitized

ASJC Scopus subject areas

  • General Medicine


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