Translating Gene Transfer: A Stalled Effort

Alexandra J. Greenberg; Jennifer Mccormick; Carmen J. Tapia; Anthony J. Windebank

doi:10.1111/j.1752-8062.2011.00297.x

Translating Gene Transfer: A Stalled Effort

Alexandra J. Greenberg, Jennifer Mccormick, Carmen J. Tapia, Anthony J. Windebank

Research output: Contribution to journal › Comment/debate › peer-review

6 Scopus citations

Abstract

The journey of gene transfer from laboratory to clinic has been slow and fraught with many challenges and barriers. Despite the development of the initial technology in the early 1970s, a standard clinical treatment involving "gene therapy" remains to be seen. Furthermore, much was written about the technology in the early 1990s, but since then, not much has been written about the journey of gene transfer. The translational path of gene transfer thus far, both pitfalls and successes, can serve as a study not only in navigating ethical and safety concerns, but also in the importance of scientist-public interactions. Here, we examine the translational progress of gene transfer and what can be gleaned from its history.

Original language	English (US)
Pages (from-to)	279-281
Number of pages	3
Journal	Clinical and translational science
Volume	4
Issue number	4
DOIs	https://doi.org/10.1111/j.1752-8062.2011.00297.x
State	Published - Aug 2011

Keywords

Commentary
Gene therapy
Viruses

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1111/j.1752-8062.2011.00297.x

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AU - Mccormick, Jennifer

AU - Tapia, Carmen J.

AU - Windebank, Anthony J.

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AB - The journey of gene transfer from laboratory to clinic has been slow and fraught with many challenges and barriers. Despite the development of the initial technology in the early 1970s, a standard clinical treatment involving "gene therapy" remains to be seen. Furthermore, much was written about the technology in the early 1990s, but since then, not much has been written about the journey of gene transfer. The translational path of gene transfer thus far, both pitfalls and successes, can serve as a study not only in navigating ethical and safety concerns, but also in the importance of scientist-public interactions. Here, we examine the translational progress of gene transfer and what can be gleaned from its history.

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KW - Viruses

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Translating Gene Transfer: A Stalled Effort

Abstract

Keywords

ASJC Scopus subject areas

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