Transdermal clonidine for ameliorating post-orchiectomy hot flashes

C. L. Loprinzi, R. M. Goldberg, J. R. O'Fallon, S. K. Quella, A. W. Miser, L. A. Mynderse, L. D. Brown, L. K. Tschetter, M. B. Wilwerding, A. M. Dose, J. E. Oesterling

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


To determine the efficacy of transdermal clonidine for alleviating post- orchiectomy hot flashes, a randomized, double-blind, crossover clinical trial was designed including 70 men with a history of prostate cancer who had undergone a medical or surgical orchiectomy and were suffering from hot flashes. The results of this study demonstrated that clonidine did not significantly decrease hot flash frequency or severity. Future research is necessary to find effective means of alleviating hot flashes in post- orchiectomy patients.

Original languageEnglish (US)
Pages (from-to)634-636
Number of pages3
JournalJournal of Urology
Issue number3
StatePublished - 1994


  • clonidine
  • flushing
  • orchiectomy
  • prostatic neoplasms

ASJC Scopus subject areas

  • Urology


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