TY - JOUR
T1 - Transcatheter Aortic Valve Replacement
T2 - State of the Art and Future Directions
AU - Eleid, MacKram F.
AU - Holmes, David R.
N1 - Publisher Copyright:
© 2017 by Annual Reviews.
PY - 2017/1/14
Y1 - 2017/1/14
N2 - Transcatheter aortic valve replacement (TAVR) is a transformational and rapidly evolving treatment for patients with aortic stenosis who require valve replacement. Novel technological advancements have made this percutaneous minimally invasive therapy a first-line treatment for many patients at extreme risk for conventional cardiac surgery. New devices and improvements in existing devices have reduced procedural complications, and scientific trials are investigating the role of TAVR in lower-risk aortic stenosis populations, in patients with aortic regurgitation, and in patients with bicuspid aortic valve disease. Finally, there is intense interest in identifying patients in whom the risk-benefit ratio of TAVR is not favorable and should not be performed.
AB - Transcatheter aortic valve replacement (TAVR) is a transformational and rapidly evolving treatment for patients with aortic stenosis who require valve replacement. Novel technological advancements have made this percutaneous minimally invasive therapy a first-line treatment for many patients at extreme risk for conventional cardiac surgery. New devices and improvements in existing devices have reduced procedural complications, and scientific trials are investigating the role of TAVR in lower-risk aortic stenosis populations, in patients with aortic regurgitation, and in patients with bicuspid aortic valve disease. Finally, there is intense interest in identifying patients in whom the risk-benefit ratio of TAVR is not favorable and should not be performed.
KW - Aortic valve disease
KW - Percutaneous therapy
KW - TAVR
KW - Transcutaneous aortic valve replacement
UR - http://www.scopus.com/inward/record.url?scp=85009952113&partnerID=8YFLogxK
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U2 - 10.1146/annurev-med-101615-020427
DO - 10.1146/annurev-med-101615-020427
M3 - Article
C2 - 27860546
AN - SCOPUS:85009952113
SN - 0066-4219
VL - 68
SP - 15
EP - 28
JO - Annual Review of Medicine
JF - Annual Review of Medicine
ER -