TY - GEN
T1 - Towards Detection of Hirschsprung's Disease using Dielectric Properties
T2 - 2023 IEEE International Symposium on Antennas and Propagation and USNC-URSI Radio Science Meeting, AP-S/URSI 2023
AU - Samaddar, Poulami
AU - Gaddam, Sunil
AU - Gopalakrishnan, Keerthy
AU - Cherukuri, Akhila
AU - Modi, Vaishnavi
AU - Dey, Shuvashis
AU - Roy, Sayan
AU - Mitra, Dipankar
AU - Arunachalam, Shivaram P.
N1 - Publisher Copyright:
© 2023 IEEE.
PY - 2023
Y1 - 2023
N2 - Hirschsprung disease is a congenital disability due to the defect in migration of colonic ganglion. Definitive diagnosis is based on the findings of histopathological evaluation of rectal biopsies which can be highly variable. Post-op perforations and bleeding are major complications of rectal biopsy. Difficulty in establishing a definitive diagnosis leads to severe complications. Research studies on the myoelectrical activity in Hirschsprung's disease have shown disorganized electrical activities and variations in spontaneous membrane activity in the affected colon. Electrical properties can be measured as complex permittivity using dielectric spectroscopy as an attempt to diagnose Hirschsprung's disease. Dielectric spectroscopy measurements on thin biological samples offer challenges due to the requirements of sample size and probe positioning. In this work, the feasibility of dielectric property measurement of thin colon of early postnatal mice using the coaxial probe method is investigated. Complex permittivity of colon tissue was calculated from simulated return loss using a previously published mathematical model and compared with measured results. The results showed very good agreement from 500 MHz to 8 GHz range and demonstrate the potential for using dielectric properties as a biomarker for Hirschsprung disease.
AB - Hirschsprung disease is a congenital disability due to the defect in migration of colonic ganglion. Definitive diagnosis is based on the findings of histopathological evaluation of rectal biopsies which can be highly variable. Post-op perforations and bleeding are major complications of rectal biopsy. Difficulty in establishing a definitive diagnosis leads to severe complications. Research studies on the myoelectrical activity in Hirschsprung's disease have shown disorganized electrical activities and variations in spontaneous membrane activity in the affected colon. Electrical properties can be measured as complex permittivity using dielectric spectroscopy as an attempt to diagnose Hirschsprung's disease. Dielectric spectroscopy measurements on thin biological samples offer challenges due to the requirements of sample size and probe positioning. In this work, the feasibility of dielectric property measurement of thin colon of early postnatal mice using the coaxial probe method is investigated. Complex permittivity of colon tissue was calculated from simulated return loss using a previously published mathematical model and compared with measured results. The results showed very good agreement from 500 MHz to 8 GHz range and demonstrate the potential for using dielectric properties as a biomarker for Hirschsprung disease.
KW - coaxial probe
KW - colon
KW - dielectric characteristics
KW - dielectric spectroscopy
KW - electromagnetic simulations
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U2 - 10.1109/USNC-URSI52151.2023.10237477
DO - 10.1109/USNC-URSI52151.2023.10237477
M3 - Conference contribution
AN - SCOPUS:85172415864
T3 - IEEE Antennas and Propagation Society, AP-S International Symposium (Digest)
SP - 1391
EP - 1392
BT - 2023 IEEE International Symposium on Antennas and Propagation and USNC-URSI Radio Science Meeting, AP-S/URSI 2023 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 23 July 2023 through 28 July 2023
ER -