Toward sophisticated basal ganglia neuromodulation: Review on basal ganglia deep brain stimulation

Claudio Da Cunha, Suelen L. Boschen, Alexander Gómez-A, Erika K. Ross, William S.J. Gibson, Hoon Ki Min, Kendall H. Lee, Charles D. Blaha

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


This review presents state-of-the-art knowledge about the roles of the basal ganglia (BG) in action-selection, cognition, and motivation, and how this knowledge has been used to improve deep brain stimulation (DBS) treatment of neurological and psychiatric disorders. Such pathological conditions include Parkinson's disease, Huntington's disease, Tourette syndrome, depression, and obsessive-compulsive disorder. The first section presents evidence supporting current hypotheses of how the cortico-BG circuitry works to select motor and emotional actions, and how defects in this circuitry can cause symptoms of the BG diseases. Emphasis is given to the role of striatal dopamine on motor performance, motivated behaviors and learning of procedural memories. Next, the use of cutting-edge electrochemical techniques in animal and human studies of BG functioning under normal and disease conditions is discussed. Finally, functional neuroimaging studies are reviewed; these works have shown the relationship between cortico-BG structures activated during DBS and improvement of disease symptoms.

Original languageEnglish (US)
Pages (from-to)186-210
Number of pages25
JournalNeuroscience and Biobehavioral Reviews
StatePublished - Nov 1 2015


  • Deep brain stimulation
  • Electrochemistry
  • Functional magnetic resonance imaging
  • Globus pallidus
  • Human
  • Pig
  • Striatum
  • Substantia nigra
  • Subthalamic nucleus
  • Voltammetry

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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