Abstract
A 70-year-old woman with dilated cardiomyopathy and ventricular tachyarrhythmia was initially treated in 1990 with intravenous amiodarone (240mg). She developed a junctional escape rhythm (48 beats/min) with QT prolongation (QT: 0.68 s) and 8 h later developed torsade de pointes (TdP). Because other antiarrhythmic drugs did not suppress the arrhythmia, oral amiodarone (100 mg/day) was started in 1995, 7 weeks before she presented with congestive heart failure. The QT prolongation (QTc: 0.64) increased after administration of dopamine, and TdP again developed. This case suggests that amiodarone induces proarrhythmias by different mechanisms when administered intravenously or orally.
Original language | English (US) |
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Pages (from-to) | 236-238 |
Number of pages | 3 |
Journal | Japanese Circulation Journal |
Volume | 65 |
Issue number | 3 |
DOIs | |
State | Published - 2001 |
Keywords
- Adrenergic-dependent
- Amiodarone
- Bradycardia-dependent
- Dilated cardiomyopathy
- Torsade de pointes
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine