Topiramate for Treatment in Patients with Migraine and Epilepsy

Scott D. Spritzer, Thomas P. Bravo, Joseph F. Drazkowski

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Background: Antiepileptic drugs (AED) are often considered first line for monotherapy in treatment of patients with migraines, and also those with comorbid migraine and epilepsy. Topiramate, a newer generation AED, has broad mechanism of action and evidence of benefit in patients with either episodic or chronic migraine along with epilepsy, both generalized and focal. Methods: Our goal is to review the relevant mechanisms of action along with any supportive evidence published to date on the use of topiramate (TPM) in patients with both migraine headache and epilepsy. Conclusions: There has been very little published to date on the use of TPM in patients diagnosed with both disorders. Despite this, TPM has been adopted as first line therapy in this patient population. Future studies investigating the effectiveness of this treatment strategy are warranted in order to determine the most effective use of this medication in patients diagnosed with migraine headaches and epilepsy.

Original languageEnglish (US)
Pages (from-to)1081-1085
Number of pages5
Issue number6
StatePublished - Jun 1 2016


  • antiepileptic drugs
  • chronic migraine
  • epilepsy
  • topiramate

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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