Topical Review Article: Medulloblastoma: I. Clinical, Diagnostic, and Therapeutic Overview

Frank H. Tomlinson, Bernd W. Scheithauer, Fredric B. Meyer, William A. Smithson, Edward G. Shaw, Gary M. Miller, Robert V. Groover

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Medulloblastoma, the most common embryonal tumor of the central nervous system, affects both children and adults. It poses a significant therapeutic challenge in that age-dependent differences exist, not only in their pathobiology, but in the efficacy of chemotherapy and radiotherapy. This is particularly the case in very young children, whose still developing nervous system exhibits a low tolerance to radiotherapy. We review the epidemiology, clinical presentation, radiologic features, and current therapeutic concepts relative to this unique neoplasm. Efforts are made to highlight clinical controversies. (J Child Neurol 1992;7:142-155).

Original languageEnglish (US)
Pages (from-to)142-155
Number of pages14
JournalJournal of child neurology
Issue number2
StatePublished - Apr 1992

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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