TY - JOUR
T1 - Topical Review Article
T2 - Medulloblastoma: I. Clinical, Diagnostic, and Therapeutic Overview
AU - Tomlinson, Frank H.
AU - Scheithauer, Bernd W.
AU - Meyer, Fredric B.
AU - Smithson, William A.
AU - Shaw, Edward G.
AU - Miller, Gary M.
AU - Groover, Robert V.
PY - 1992/4
Y1 - 1992/4
N2 - Medulloblastoma, the most common embryonal tumor of the central nervous system, affects both children and adults. It poses a significant therapeutic challenge in that age-dependent differences exist, not only in their pathobiology, but in the efficacy of chemotherapy and radiotherapy. This is particularly the case in very young children, whose still developing nervous system exhibits a low tolerance to radiotherapy. We review the epidemiology, clinical presentation, radiologic features, and current therapeutic concepts relative to this unique neoplasm. Efforts are made to highlight clinical controversies. (J Child Neurol 1992;7:142-155).
AB - Medulloblastoma, the most common embryonal tumor of the central nervous system, affects both children and adults. It poses a significant therapeutic challenge in that age-dependent differences exist, not only in their pathobiology, but in the efficacy of chemotherapy and radiotherapy. This is particularly the case in very young children, whose still developing nervous system exhibits a low tolerance to radiotherapy. We review the epidemiology, clinical presentation, radiologic features, and current therapeutic concepts relative to this unique neoplasm. Efforts are made to highlight clinical controversies. (J Child Neurol 1992;7:142-155).
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U2 - 10.1177/088307389200700203
DO - 10.1177/088307389200700203
M3 - Review article
C2 - 1573231
AN - SCOPUS:0026749714
SN - 0883-0738
VL - 7
SP - 142
EP - 155
JO - Journal of child neurology
JF - Journal of child neurology
IS - 2
ER -