Topical Cannabinoids for Treating Chemotherapy-Induced Neuropathy: A Case Series

Stacy D’Andre, Sean McAllister, Jasdeepa Nagi, Karthik V. Giridhar, Eduardo Ruiz-Macias, Charles Loprinzi

Research output: Contribution to journalArticlepeer-review


Background: Chemotherapy-induced peripheral neuropathy is a common and often severe side effect from many chemotherapeutic agents, with limited treatment options. There is no literature on the use of topical cannabinoids for chemotherapy-induced neuropathy. Case Presentations: The current manuscript presents a case series of patients presenting in oncology clinics at Sutter Health, CA and Mayo Clinic, Rochester, MN from April 2019 to December 2020 with chemotherapy-induced peripheral neuropathy who used topical creams containing the cannabinoids delta-nine-tetrahydrocannabinol (THC) and/or cannabidiol (CBD). Conclusions: This case series suggests that topical cannabinoids may be helpful for patients with chemotherapy-induced peripheral neuropathy. This paper also discusses the potential mechanisms of action by which topical cannabinoids might alleviate established CIPN symptoms. A randomized placebo-controlled trial using a standardized product is planned to study the actual efficacy of such treatment.

Original languageEnglish (US)
JournalIntegrative Cancer Therapies
StatePublished - Nov 2021


  • CBD
  • cannabinoids
  • chemotherapy-induced peripheral neuropathy
  • topicals

ASJC Scopus subject areas

  • Oncology
  • Complementary and alternative medicine


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