TY - JOUR
T1 - Topical Cannabinoids for Treating Chemotherapy-Induced Neuropathy
T2 - A Case Series
AU - D’Andre, Stacy
AU - McAllister, Sean
AU - Nagi, Jasdeepa
AU - Giridhar, Karthik V.
AU - Ruiz-Macias, Eduardo
AU - Loprinzi, Charles
N1 - Publisher Copyright:
© The Author(s) 2021.
PY - 2021/11
Y1 - 2021/11
N2 - Background: Chemotherapy-induced peripheral neuropathy is a common and often severe side effect from many chemotherapeutic agents, with limited treatment options. There is no literature on the use of topical cannabinoids for chemotherapy-induced neuropathy. Case Presentations: The current manuscript presents a case series of patients presenting in oncology clinics at Sutter Health, CA and Mayo Clinic, Rochester, MN from April 2019 to December 2020 with chemotherapy-induced peripheral neuropathy who used topical creams containing the cannabinoids delta-nine-tetrahydrocannabinol (THC) and/or cannabidiol (CBD). Conclusions: This case series suggests that topical cannabinoids may be helpful for patients with chemotherapy-induced peripheral neuropathy. This paper also discusses the potential mechanisms of action by which topical cannabinoids might alleviate established CIPN symptoms. A randomized placebo-controlled trial using a standardized product is planned to study the actual efficacy of such treatment.
AB - Background: Chemotherapy-induced peripheral neuropathy is a common and often severe side effect from many chemotherapeutic agents, with limited treatment options. There is no literature on the use of topical cannabinoids for chemotherapy-induced neuropathy. Case Presentations: The current manuscript presents a case series of patients presenting in oncology clinics at Sutter Health, CA and Mayo Clinic, Rochester, MN from April 2019 to December 2020 with chemotherapy-induced peripheral neuropathy who used topical creams containing the cannabinoids delta-nine-tetrahydrocannabinol (THC) and/or cannabidiol (CBD). Conclusions: This case series suggests that topical cannabinoids may be helpful for patients with chemotherapy-induced peripheral neuropathy. This paper also discusses the potential mechanisms of action by which topical cannabinoids might alleviate established CIPN symptoms. A randomized placebo-controlled trial using a standardized product is planned to study the actual efficacy of such treatment.
KW - CBD
KW - cannabinoids
KW - chemotherapy-induced peripheral neuropathy
KW - topicals
UR - http://www.scopus.com/inward/record.url?scp=85120539656&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85120539656&partnerID=8YFLogxK
U2 - 10.1177/15347354211061739
DO - 10.1177/15347354211061739
M3 - Article
C2 - 34841942
AN - SCOPUS:85120539656
SN - 1534-7354
VL - 20
JO - Integrative Cancer Therapies
JF - Integrative Cancer Therapies
ER -