Tolerance to morphine-induced mydriasis in the rat pupil

Charles H. Adler; Michael Robin; Martin W. Adler

doi:10.1016/0024-3205(81)90588-9

Tolerance to morphine-induced mydriasis in the rat pupil

Charles H. Adler, Michael Robin, Martin W. Adler

Neurology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Despite the commonly held view that tolerance does not develop to the pupillary effects of narcotics, recent studies have demonstrated tolerance to heroin-induced miosis in humans and to morphine-induced mydriasis in the mouse. Previous studies in this laboratory have shown that morphine produces a dose-related mydriasis and fluctuation (large amplitude, irregular oscillations in pupil diameter) in the rat pupil; the present study was designed to determine if tolerance develops to these effects following subcutaneous implantation of morphine pellets. We found that there is, indeed, tolerance to the morphine-induced mydriasis, but it is not complete. Furthermore, statistically significant tolerance does not develop to morphine-induced fluctuations in the rat pupil.

Original language	English (US)
Pages (from-to)	2469-2475
Number of pages	7
Journal	Life Sciences
Volume	28
Issue number	22
DOIs	https://doi.org/10.1016/0024-3205(81)90588-9
State	Published - Jun 1 1981

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(81)90588-9

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abstract = "Despite the commonly held view that tolerance does not develop to the pupillary effects of narcotics, recent studies have demonstrated tolerance to heroin-induced miosis in humans and to morphine-induced mydriasis in the mouse. Previous studies in this laboratory have shown that morphine produces a dose-related mydriasis and fluctuation (large amplitude, irregular oscillations in pupil diameter) in the rat pupil; the present study was designed to determine if tolerance develops to these effects following subcutaneous implantation of morphine pellets. We found that there is, indeed, tolerance to the morphine-induced mydriasis, but it is not complete. Furthermore, statistically significant tolerance does not develop to morphine-induced fluctuations in the rat pupil.",

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AB - Despite the commonly held view that tolerance does not develop to the pupillary effects of narcotics, recent studies have demonstrated tolerance to heroin-induced miosis in humans and to morphine-induced mydriasis in the mouse. Previous studies in this laboratory have shown that morphine produces a dose-related mydriasis and fluctuation (large amplitude, irregular oscillations in pupil diameter) in the rat pupil; the present study was designed to determine if tolerance develops to these effects following subcutaneous implantation of morphine pellets. We found that there is, indeed, tolerance to the morphine-induced mydriasis, but it is not complete. Furthermore, statistically significant tolerance does not develop to morphine-induced fluctuations in the rat pupil.

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Tolerance to morphine-induced mydriasis in the rat pupil

Abstract

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