@article{25e38368a8d14377bf9e41ffb129b58f,
title = "Tissue methylated DNA markers for sporadic pancreatic cancer are strongly associated with familial and genetically predisposed pancreatic cancer",
abstract = "High-risk individuals (HRIs) with familial and genetic predisposition to pancreatic ductal adenocarcinoma (PDAC) are eligible for screening. There is no accurate biomarker for detecting early-stage PDAC. We previously demonstrated that a panel of methylated DNA markers (MDMs) accurately detect sporadic PDAC. In this study we compared the distribution of MDMs in DNA extracted from tissue of PDAC cases who carry germline mutations and non-carriers with family history, with control tissue and demonstrate high discrimination like that seen in sporadic PDAC. These results provide scientific rationale for examining plasma MDMs in HRIs with the goal of developing a minimally-invasive early detection test.",
keywords = "Biomarker, DNA methylation, Pancreatic cancer",
author = "Shounak Majumder and Taylor, {William R.} and Foote, {Patrick H.} and Gysbers, {Brianna J.} and Xiaoming Cao and Mahoney, {Douglas W.} and Burger, {Kelli N.} and Doering, {Karen A.} and Graham, {Rondell P.} and Couch, {Fergus J.} and Petersen, {Gloria M.} and Kisiel, {John B.}",
note = "Funding Information: Mayo Clinic and Exact Sciences have an intellectual property development agreement. Drs. Majumder & Kisiel and Messrs. Taylor & Mahoney are listed as inventors under this agreement and could share potential future royalties paid to Mayo Clinic. The other authors of this manuscript have no conflicts of interest to declare. The abstract summarizing results from this study was presented at Virtual Digestive Disease Week 2021. Support was provided by the Centene Charitable Foundation (to SM and GMP), CA102701 (to GMP), CA214679 (to JBK), and a sponsored research agreement between Mayo Clinic and Exact Sciences. Additional support from Tissue Registry, Biospecimens Accession & Processing, and Pathology Research Core shared recourses of the Mayo Clinic Cancer Center Support Grant ( P30 CA015083 ). Publisher Copyright: {\textcopyright} 2022",
year = "2022",
doi = "10.1016/j.pan.2022.06.259",
language = "English (US)",
journal = "Pancreatology",
issn = "1424-3903",
publisher = "S. Karger AG",
}