Tipping the balance: MTDH-SND1 curbs oncogene-induced apoptosis and promotes tumorigenesis

Nagarajan Kannan; Connie J. Eaves

doi:10.1016/j.stem.2014.07.010

Tipping the balance: MTDH-SND1 curbs oncogene-induced apoptosis and promotes tumorigenesis

Nagarajan Kannan, Connie J. Eaves

Laboratory Medicine and Pathology

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

Tumorigenesis is a complex and poorly understood process in which oncogenes can activate competing proapoptotic and proneoplastic programs. A recent paper in Cancer Cell demonstrates a dual role of the MTDH-SND1 complex in suppressing the apoptotic response and promoting breast cancer development, suggesting a new therapeutic avenue.

Original language	English (US)
Pages (from-to)	118-120
Number of pages	3
Journal	Cell Stem Cell
Volume	15
Issue number	2
DOIs	https://doi.org/10.1016/j.stem.2014.07.010
State	Published - Aug 7 2014

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

Access to Document

10.1016/j.stem.2014.07.010

Cite this

@article{980203fde5c546a0838396a07e3d74b5,

title = "Tipping the balance: MTDH-SND1 curbs oncogene-induced apoptosis and promotes tumorigenesis",

abstract = "Tumorigenesis is a complex and poorly understood process in which oncogenes can activate competing proapoptotic and proneoplastic programs. A recent paper in Cancer Cell demonstrates a dual role of the MTDH-SND1 complex in suppressing the apoptotic response and promoting breast cancer development, suggesting a new therapeutic avenue.",

author = "Nagarajan Kannan and Eaves, {Connie J.}",

year = "2014",

month = aug,

day = "7",

doi = "10.1016/j.stem.2014.07.010",

language = "English (US)",

volume = "15",

pages = "118--120",

journal = "Cell Stem Cell",

issn = "1934-5909",

publisher = "Cell Press",

number = "2",

}

TY - JOUR

T1 - Tipping the balance

T2 - MTDH-SND1 curbs oncogene-induced apoptosis and promotes tumorigenesis

AU - Kannan, Nagarajan

AU - Eaves, Connie J.

PY - 2014/8/7

Y1 - 2014/8/7

N2 - Tumorigenesis is a complex and poorly understood process in which oncogenes can activate competing proapoptotic and proneoplastic programs. A recent paper in Cancer Cell demonstrates a dual role of the MTDH-SND1 complex in suppressing the apoptotic response and promoting breast cancer development, suggesting a new therapeutic avenue.

AB - Tumorigenesis is a complex and poorly understood process in which oncogenes can activate competing proapoptotic and proneoplastic programs. A recent paper in Cancer Cell demonstrates a dual role of the MTDH-SND1 complex in suppressing the apoptotic response and promoting breast cancer development, suggesting a new therapeutic avenue.

UR - http://www.scopus.com/inward/record.url?scp=84905816568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905816568&partnerID=8YFLogxK

U2 - 10.1016/j.stem.2014.07.010

DO - 10.1016/j.stem.2014.07.010

M3 - Short survey

C2 - 25105576

AN - SCOPUS:84905816568

SN - 1934-5909

VL - 15

SP - 118

EP - 120

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 2

ER -

Tipping the balance: MTDH-SND1 curbs oncogene-induced apoptosis and promotes tumorigenesis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this