Time delay for arrival of MR contrast agent in collateral-dependent myocardium

Michael Jerosch-Herold, Xudong Hu, Naveen S. Murthy, Ravi T. Seethamraju

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


An analysis of the kinetics of myocardial contrast enhancement is an important component of myocardial perfusion studies. The contrast enhancement can be modeled by a linear time-invariant system, and the myocardial impulse response, calculated by deconvolution of the measured tissue response with an arterial input, gives a direct estimate of myocardial blood flow. In this paper, we analyze the effects of delays in the contrast enhancement, that occur in collateral-dependent myocardium, where the tracer reaches the tissue region only through branches from other coronary arteries that form natural bypass vessels. We investigate how the delayed arrival of tracer alters the myocardial impulse response. Model-independent deconvolution is applied to determine the lag between arterial input and tissue enhancement. Experimental data in a porcine model of collateral development indicate that the delayed arrival of an injected tracer, measured at rest, is a useful marker to identify collateral-dependent myocardium, and predict its flow capacitance.

Original languageEnglish (US)
Pages (from-to)881-890
Number of pages10
JournalIEEE transactions on medical imaging
Issue number7
StatePublished - Jul 2004


  • Collateral circulation
  • Deconvolution
  • Magnetic resonance imaging
  • Myocardial blood flow
  • Tikhonov regularization

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering


Dive into the research topics of 'Time delay for arrival of MR contrast agent in collateral-dependent myocardium'. Together they form a unique fingerprint.

Cite this