TIA-1 expression in lymphoid neoplasms: Identification of subsets with cytotoxic T lymphocyte or natural killer cell differentiation

Raymond E. Felgar, William R. Macon, Marsha C. Kinney, Shelley Roberts, Theresa Pasha, Kevin E. Salhany

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127 Scopus citations


TIA-1 is a 15-kd cytotoxic granule-associated protein expressed in natural killer (NK) cells and cytotoxic T lymphocytes. TIA-1 expression was evaluated by paraffin immunohistochemistry in 115 T-or NK-cell neoplasms, 45 B-cell neoplasms, and 45 Hodgkin's lymphomas. TIA-1-positive granules were identified within the cytoplasm of neoplastic cells in 6/6 large granular lymphocytic leukemias, 11/11 hepatosplenic T-cell lymphomas, 15/15 intestinal T-cell lymphomas, 6/6 NK-like T-cell lymphomas of no special type, 2/2 NK- cell lymphomas, 8/9 nasal T/NK-cell lymphomas, 7/8 subcutaneous T-cell lymphomas, 4/5 pulmonary, T- or NK-cell angiocentric lymphomas (lymphomatoid granulomatosis), 12/19 T-cell anaplastic large-cell lymphomas. 2/12 nodal peripheral T-cell lymphomas, 1/3 CD8+ cutaneous T=cell lymphomas, and 5/38 classical Hodgkin's disease. All B-cell neoplasms, nodular lymphocyte- predominant Hodgkin's disease (7 cases), CD4+ cutaneous T-cell lymphomas (6 cases), adult T-cell leukemia/lymphomas (3 cases), T-cell chronic or prolymphocytic leukemias (3 cases), and T-cell lymphoblastic leukemia/lymphomas (7 cases) were TIA-1 negative. These findings indicate that most large granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas, pulmonary angiocentric lymphomas of T or NK phenotype, and anaplastic large- cell lymphomas are cytotoxic T or NK-cell neoplasms.

Original languageEnglish (US)
Pages (from-to)1893-1900
Number of pages8
JournalAmerican Journal of Pathology
Issue number6
StatePublished - 1997

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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