Thyroid Nodule Size as a Predictor of Malignancy in Follicular and Hurthle Neoplasms

Arunnit Boonrod, Zeynettin Akkus, M. Regina Castro, Atefeh Zeinodini, Kenneth Philbrick, Marius Stan, Dana Erickson, Bradley Erickson

Research output: Contribution to journalArticlepeer-review


Introduction: The management of follicular (FN) and Hurthle cell neoplasms (HCN) is often difficult because of the uncertainty of malignancy risk. We aimed to assess characteristics of benign and malignant follicular and Hurthle neoplasms based on their shape and size. Materials and methods: Patients with Follicular adenoma (FA) or carcinoma (FC) and Hurthle Cell adenoma (HCA) or carcinoma (HCC) who had preoperative ultrasonography were included. Demographic data were retrieved. Size and shape of the nodules were measured. Logistic regression analyses and odds ratios were performed. Results: A total of 115 nodules with 57 carcinomas and 58 adenomas were included. Logistic regression analysis shows that the nodule height and the patient age are predictors of malignancy (p-values = 0.001 and 0.042). A cutoff value of nodule height > 4 cm. produces an odds ratio of 4.5 (p-value = 0.006). An age > 55 year-old demonstrates an odds ratio of 2.4-3.6 (p-value = 0.03). Taller-than-wide shape was not statistically significant (p-value = 0.613). Conclusion: FC and HCC are larger than FA and HCA in size, with a cutoff at 4 cm. Increasing age increases the odds of malignancy with a cutoff at 55 year-old. Taller-than-wide shape is not a predictor of malignancy.

Original languageEnglish (US)
Pages (from-to)2597-2602
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Issue number8
StatePublished - Aug 2021


  • Follicular neoplasm- hurthle cell neoplasm- size- taller-than-wide

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research


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