Thyroid dermopathy and acropachy

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Graves' disease is an autoimmune condition with extrathyroidal immune-mediated manifestations, including ophthalmopathy and dermopathy. Dermopathy, or pretibial myxedema, typically occurs in patients with ophthalmopathy. The presence of high levels of thyrotropin receptor antibodies indicates a more severe autoimmune process. Diagnosis is on recognition of clinical features; skin biopsy may be needed in some cases. One in four patients with thyroid dermopathy, usually occurring in the pretibial area, has acropachy and digital clubbing. Localization to the pretibial area is most likely due to dependency and mechanical factors. Rarely, upper body involvement occurs, usually triggered by trauma. Mild cases resolve over time. Moderate or severe cases require local corticosteroid therapy. Severe cases, including elephantiasis, are usually persistent and mimic lymphedema.

Original languageEnglish (US)
Pages (from-to)75-90
Number of pages16
JournalExpert Review of Dermatology
Issue number1
StatePublished - Feb 2011


  • Graves' disease
  • Graves' ophthalmopathy
  • antithyroid antibodies
  • autoimmune diseases
  • glycosaminoglycans
  • hyperthyroidism
  • rituximab
  • thyroid dermopathy
  • thyroid gland

ASJC Scopus subject areas

  • Dermatology


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