Abstract
Objectives: To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder. Methods: Clinician-adjusted self-ratings of mood were completed daily for oneyear for naturalistically treated outpatients with bipolar I (n=405) or bipolar II (n=102) disorder. Ratings were analyzed for mean time spent euthymic, depressed, manic, hypomanic, and cycling, and the percentages of time spent ill were compared between the two groups. Results: Percentages of time spent ill for bipolar I versus II patients were: euthymia 47.7% versus 50.2% depression 36.0% versus 37.0%; hypomania 11.5% versus 9.8%; mania 1.0% versus 0.2%; and cycling 3.7% versus 2.8%. The depression/mania ratio was 2.9 in the bipolar I and 3.8 in bipolar II sub-groups. Conclusion: Depression represents the predominant abnormal mood state for treated outpatients with bipolar I and II disorder. In contrast to other studies, we found that depression/mania ratios were of a similar magnitude, suggesting the same tendency towards mood instability in both sub-groups.
Original language | English (US) |
---|---|
Pages (from-to) | 531-535 |
Number of pages | 5 |
Journal | Bipolar disorders |
Volume | 9 |
Issue number | 5 |
DOIs | |
State | Published - Aug 2007 |
Keywords
- Bipolar I disorder
- Bipolar II disorder
- Course of illness
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry