Three-dimensional bioprinting strategies for tissue engineering

Yu Shrike Zhang, Rahmi Oklu, Mehmet Remzi Dokmeci, Ali Khademhosseini

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Over the past decades, many approaches have been developed to fabricate biomimetic extracellular matrices of desired properties for engineering functional tissues. However, the inability of these techniques to precisely control the spatial architecture has posed a significant challenge in producing complex tissues. 3D bioprinting technology has emerged as a potential solution by bringing unprecedented freedom and versatility in depositing biological materials and cells in a well-controlled manner in the 3D volumes, therefore achieving precision engineering of functional tissues. In this article, we review the application of 3D bioprinting to tissue engineering. We first discuss the general strategies for printing functional tissue constructs. We next describe different types of bioprinting with a focus on nozzle-based techniques and their respective advantages. Finally, we summarize the limitations of current technologies and propose challenges for future development of bioprinting.

Original languageEnglish (US)
Article numbera025718
JournalCold Spring Harbor Perspectives in Medicine
Issue number2
StatePublished - Feb 2018

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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