TY - JOUR
T1 - Three-dimensional bioprinting strategies for tissue engineering
AU - Zhang, Yu Shrike
AU - Oklu, Rahmi
AU - Dokmeci, Mehmet Remzi
AU - Khademhosseini, Ali
N1 - Publisher Copyright:
© 2018 Cold Spring Harbor Laboratory Press; all rights reserved.
PY - 2018/2
Y1 - 2018/2
N2 - Over the past decades, many approaches have been developed to fabricate biomimetic extracellular matrices of desired properties for engineering functional tissues. However, the inability of these techniques to precisely control the spatial architecture has posed a significant challenge in producing complex tissues. 3D bioprinting technology has emerged as a potential solution by bringing unprecedented freedom and versatility in depositing biological materials and cells in a well-controlled manner in the 3D volumes, therefore achieving precision engineering of functional tissues. In this article, we review the application of 3D bioprinting to tissue engineering. We first discuss the general strategies for printing functional tissue constructs. We next describe different types of bioprinting with a focus on nozzle-based techniques and their respective advantages. Finally, we summarize the limitations of current technologies and propose challenges for future development of bioprinting.
AB - Over the past decades, many approaches have been developed to fabricate biomimetic extracellular matrices of desired properties for engineering functional tissues. However, the inability of these techniques to precisely control the spatial architecture has posed a significant challenge in producing complex tissues. 3D bioprinting technology has emerged as a potential solution by bringing unprecedented freedom and versatility in depositing biological materials and cells in a well-controlled manner in the 3D volumes, therefore achieving precision engineering of functional tissues. In this article, we review the application of 3D bioprinting to tissue engineering. We first discuss the general strategies for printing functional tissue constructs. We next describe different types of bioprinting with a focus on nozzle-based techniques and their respective advantages. Finally, we summarize the limitations of current technologies and propose challenges for future development of bioprinting.
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U2 - 10.1101/cshperspect.a025718
DO - 10.1101/cshperspect.a025718
M3 - Article
C2 - 28289247
AN - SCOPUS:85036476525
SN - 2157-1422
VL - 8
JO - Cold Spring Harbor Perspectives in Medicine
JF - Cold Spring Harbor Perspectives in Medicine
IS - 2
M1 - a025718
ER -