TY - JOUR
T1 - Thermal ablative therapies and immune checkpoint modulation
T2 - Can locoregional approaches effect a systemic response?
AU - Mehta, Amol
AU - Oklu, Rahmi
AU - Sheth, Rahul A.
N1 - Publisher Copyright:
© 2016 Amol Mehta et al.
PY - 2016
Y1 - 2016
N2 - Percutaneous image-guided ablation is an increasingly common treatment for a multitude of solid organ malignancies. While historically these techniques have been restricted to the management of small, unresectable tumors, there is an expanding appreciation for the systemic effects these locoregional interventions can cause. In this review, we summarize the mechanisms of action for the most common thermal ablation modalities and highlight the key advances in knowledge regarding the interactions between thermal ablation and the immune system.
AB - Percutaneous image-guided ablation is an increasingly common treatment for a multitude of solid organ malignancies. While historically these techniques have been restricted to the management of small, unresectable tumors, there is an expanding appreciation for the systemic effects these locoregional interventions can cause. In this review, we summarize the mechanisms of action for the most common thermal ablation modalities and highlight the key advances in knowledge regarding the interactions between thermal ablation and the immune system.
UR - http://www.scopus.com/inward/record.url?scp=84961919088&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961919088&partnerID=8YFLogxK
U2 - 10.1155/2016/9251375
DO - 10.1155/2016/9251375
M3 - Review article
AN - SCOPUS:84961919088
SN - 1687-6121
VL - 2016
JO - Gastroenterology Research and Practice
JF - Gastroenterology Research and Practice
M1 - 9251375
ER -