There is an exception to every rule—T2-FLAIR mismatch sign in gliomas

Derek R. Johnson, Timothy J. Kaufmann, Sohil H. Patel, Andrew S. Chi, Matija Snuderl, Rajan Jain

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The T2-FLAIR mismatch sign, in which a low-grade glioma is hyperintense on T2-weighted MR and centrally hypointense on T2-weighted FLAIR MR, has been reported as 100% specific for IDH-mutant astrocytomas in several series. We report several cases of “false positive” T2-FLAIR mismatch sign occurring outside the context of IDH-mutant astrocytomas, predominantly in children or young adults with pediatric-type gliomas. These results suggest caution in the interpretation of the T2-FLAIR mismatch sign in the pediatric glioma population.

Original languageEnglish (US)
Pages (from-to)225-227
Number of pages3
Issue number2
StatePublished - Feb 11 2019


  • Glioma
  • IDH-mutation
  • MRI
  • Mismatch

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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