Therapeutic targeting strategies of cancer stem cells in gastrointestinal malignancies

Mohamad B. Sonbol, Daniel H. Ahn, Tanios Bekaii-Saab

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Cancer stem cells (CSCs) are thought to be a distinct population of cells within a tumor mass that are capable of asymmetric division and known to have chemoresistant characteristics. The description and identification of CSC models in cancer growth and recurrence has inspired the design of novel treatment strategies to overcome treatment resistance by targeting both CSCs and non-CSC tumor cells. Several cellular signaling pathways have been described as playing a role in the induction and maintenance of stemness in CSCs, such as the Wnt/β-catenin, Notch, STAT3, and Hedgehog pathways. In this review, we aim to review some of the ongoing CSC therapeutic targeting strategies in gastrointestinal malignancies.

Original languageEnglish (US)
Article number17
Issue number1
StatePublished - Mar 1 2019


  • BBI-608
  • Colorectal cancer
  • Gastric cancer
  • Napabucasin
  • Pancreatic cancer
  • STAT3
  • Wnt/β-catenin
  • cancer stem cell

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • General Biochemistry, Genetics and Molecular Biology


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