Abstract
Continuous subcutaneous administration of polyamine-modified catalase that has increased permeability at the blood-brain barrier showed both a highly significant delay in onset and an increase in survival in a transgenic mouse model of familial amyotrophic lateral sclerosis having a point mutation in the gene encoding copper/zinc superoxide dismutase. These results suggest that hydrogen peroxide-mediated oxidative stress with subsequent free radical damage involving nitric oxide and possibly hydroxyl radicals in motor neurons may be the culprit in familial amyotrophic lateral sclerosis.
Original language | English (US) |
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Pages (from-to) | 943-947 |
Number of pages | 5 |
Journal | Annals of neurology |
Volume | 48 |
Issue number | 6 |
DOIs | |
State | Published - 2000 |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology