The yin and yang of autophagy in AL amyloidosis

Research output: Contribution to journalComment/debatepeer-review

2 Scopus citations


In this issue of Blood, Oliva et al report on a series of experiments that have demonstrated that in systemic light chain (AL) plasma cells (PCs), there is a complex interaction between those PCs and the immunoglobulin light chains (LCs) they produce.1 The pathology introduced by these unstable amyloidogenic LCs occurs not only at distant organs2,3 but also in the plasma cells that produce them. This manuscript attempts to unravel the relationship of AL LCs and the PCs that produce them in the context of AL PC susceptibility to proteasome inhibitors and the role autophagy may play in that susceptibility.

Original languageEnglish (US)
Pages (from-to)2044-2045
Number of pages2
Issue number15
StatePublished - Apr 13 2017

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


Dive into the research topics of 'The yin and yang of autophagy in AL amyloidosis'. Together they form a unique fingerprint.

Cite this