@article{7d7e31c004484e3ea76d2ca5e38d7996,
title = "The Volume-Outcome Effect Calls for Centralization of Care in Esophageal Adenocarcinoma: Results From a Large National Cancer Registry",
abstract = "INTRODUCTION:Using the National Cancer Database, we assessed the relationship between facility overall esophageal adenocarcinoma (EAC) case volume and survival.METHODS:We categorized facilities into volume quintiles based on annual EAC patient volume and performed a multivariable Cox proportional hazards regression between facility patient volume and survival.RESULTS:In a cohort of 116,675 patients, facilities with higher vs lower (≥25 vs 1-4 cases) annual EAC patient volume demonstrated improved survival (adjusted hazard ratio: 0.80. 95% confidence interval: 0.70-0.91).DISCUSSION:This robust volume-outcome effect calls for centralization of care for EAC patients at high annual case volume facilities.",
author = "Samuel Han and Kolb, {Jennifer M.} and Patrick Hosokawa and Chloe Friedman and Charlie Fox and Scott, {Frank I.} and Lieu, {Christopher H.} and Vajravelu, {Ravy K.} and Martin McCarter and Murphy, {Caitlin C.} and Cook, {Michael B.} and Ana Gleisner and Falk, {Gary W.} and Katzka, {David A.} and Sachin Wani",
note = "Funding Information: Financial support: S.H.: Received funding from National Institutes of Health (NIH) T32-DK007038. J.M.K.: Received funding from National Institutes of Health (NIH) T32-DK007038. F.I.S.: Received research funding from the National Institutes of Health/NIDDK (K08-DK095951), Crohn's and Colitis Foundation, and investigator-initiated grants from Takeda Pharmaceuticals USA and Janssen Pharmaceuticals. Consultant for PRIME Incorporated, Janssen Pharmaceuticals, Takeda Pharmaceuticals, and Merck Pharmaceuticals. R.K.V.: Received funding from National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); K08-DK119475. C.C.M.: Received funding from the National Institutes of Health; NIH R01CA242558. G.W.F.: Consultant for CDx, Interpace, and Cernostics and received funding from National Institutes of Health; NIH P30-DK050306 and U54-CA163004. D.A.K.: Advisory board member of Celgene and Shire. S.W.: Received funding from the University of Colorado Department of Medicine Outstanding Early Scholars Award, Consultant for Medtronic, Boston Scientific, Interpace, and Cernostics. Publisher Copyright: {\textcopyright} 2021 Wolters Kluwer Health. All rights reserved.",
year = "2021",
month = apr,
day = "1",
doi = "10.14309/ajg.0000000000001046",
language = "English (US)",
volume = "116",
pages = "811--815",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "4",
}