The Utility of High Intensity Interval Training to Improve Cognitive Aging in Heart Disease Patients

Jenna L. Taylor, Jill N. Barnes, Bruce D. Johnson

Research output: Contribution to journalReview articlepeer-review


Adults with cardiovascular disease and heart failure are at higher risk of cognitive decline. Cerebral hypoperfusion appears to be a significant contributor, which can result from vascular dysfunction and impairment of cerebral blood flow regulation. In contrast, higher cardiorespiratory fitness shows protection against brain atrophy, reductions in cerebral blood flow, and cognitive decline. Given that high intensity interval training (HIIT) has been shown to be a potent stimulus for improving cardiorespiratory fitness and peripheral vascular function, its utility for improving cognitive aging is an important area of research. This article will review the physiology related to cerebral blood flow regulation and cognitive decline in adults with cardiovascular disease and heart failure, and how HIIT may provide a more optimal stimulus for improving cognitive aging in this population.

Original languageEnglish (US)
Article number16926
JournalInternational journal of environmental research and public health
Issue number24
StatePublished - Dec 2022


  • brain
  • cardiac rehabilitation
  • cardiovascular disease
  • cerebral blood flow
  • cerebrovascular function
  • cognitive function
  • exercise
  • gray matter
  • heart failure
  • white matter

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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