The two faces of regulatory t cells in cancer

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Regulatory T cells (Tregs) that expand in human colon cancer express retinoid-related orphan receptor γt (RORγt) and exert potent T-cell suppressive functions while mediating pro-inflammatory effects. Similar Tregs expand and drive a vicious cycle of inflammation in murine polyposis. Targeting RORγt in Tregs interrupts such a cycle and protects mice against polyposis, suggesting that a similar intervention may provide therapeutic benefits to colon cancer patients.

Original languageEnglish (US)
Article numbere23852
Issue number5
StatePublished - May 2013


  • Colon-cancer
  • Inflammation
  • Polyposis
  • RORγt
  • Treg

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology


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